文献

  1. F. Cavalie(1995)神様が忘れた娘(ジャンヌ・カルマン120年の人生)(木村佐代子 訳、イーストプレス)

  2. R. Arking (2000) 老化のバイオロジー(鍋島陽一 北徹 石川冬木 監訳、メディカル・サイエンス・インターナショナル)

  3. B. Levin (2000) Genes VII, Oxford Univ. Press & Cell Press

  4. J. Z. Morris, H. A. Tissenbaum & G. Ruvkun (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536-539

  5. P. L. Larsen, P. S. Albert & D. L. Riddle (1995) Genetics 139, 1567-1583

  6. H. Hsin & C. Kenyon (1999) Nature 399, 362-366

  7. B. Lakowski & S. Hekimi (1996) : Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272: 1010-1013

  8. Y. Honda & S. Honda (1999) The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J 13, 1385-1394

  9. J. Taub et al (1999) Nature 399, 162-166

  10. S. Melov et al (2000) Science 289, 1567-1569

  11. K. Baker et al (1998) J. Pharmacol. Exp. Ther. 284, 215-221

    資料の文献

  12. S. Brenner (1974) Genetics 77, 71-94

  13. J. Hodgkin et al. (1998) C. elegans: Sequence to Biology, Science 282, 2011-2046

  14. D. Riddle, T. Blumental, B. J. Meyer & J. R. Priess. (1997) C. elegans II, Cold Spring Harbor Laboratory Press, Plainview, NY

  15. C. Kenyon C (1997) : Environmental factors and gene activities that influence life span. In C. elegans II (Riddle DL, Blumenthal T, Meyer BJ, et al eds) pp. 791-813, Cold Spring Harbor Lab. Press, Plainview, N.Y.

  16. T. E. Johnson (1990): Increased life-span of age-1 mutants in Caenorhabditis elegans and lower gomperz rate of aging. Science 249: 908-912

  17. D. Gems D et al (1998): Two pleiotropic class of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150: 129-155

  18. D. L. Riddle & P. S. Albert (1997): Genetic and environmental regulation of dauer larva development. In C. elegans II (Riddle DL, Blumenthal T, Meyer BJ, et al eds), pp. 739-768, Cold Spring Harbor Lab. Press, Plainview, N.Y.

  19. K. D. Kimura et al (1997): daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946

  20. F. M. Gregoire et al (1998): Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegans. Biochem Biophys Res Comm. 249: 385-90

  21. S. Ogg & G. Ruvkun (1998): The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2: 887-893

  22. S. Paradis S & G. Ruvkun (1998): Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes & Devel. 12: 2488-2498

  23. S. Ogg et al (1997): The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature (London) 389: 994-999

  24. K. Lin K et al (1997): daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322

  25. A. Brunet et al (1999): Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868

  26. Benard.C, McCright B, Zhang Y, Felkai S, Lakowski B, Hekimi S. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length. Development 2001;128: 4045-4055. T. Jonassen et al (1998): Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis. J Biol Chem 273: 3351-3357

  27. Lim CS, Mian IS, Dernburg AF, Campisi J. C. elegans clk-2, a gene that limits life span, encodes a telomere length regulator similar to yeast telomere binding protein Tel2p. Curr Biol. 2001 11: 1706-1710. S. Felkai et al (1999): CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J 18: 1783-1792

  28. Ahmed S, Alpi A, Hengartner MO, Gartner A. C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Curr Biol. 2001 11:1934-1944.

  29. Lemieux J, Lakowski B, Webb A, Meng Y, Ubach A, Bussiere F, Barnes T, Hekimi S. Regulation of Physiological Rates in Caenorhabditis elegans by a tRNA-Modifying Enzyme in the Mitochondria. Genetics. 2001 159: 147-157.

  30. S. Asaumi, H. Kuroyanagi, N. Seki & T. Shirasawa (1999) Genomics 58, 293-301

  31. S. Rea (2001): CLK-1/Coq7p is a DMQ mono-oxygenase and a new member of the di-iron carboxylate protein family. FEBS Lett. 509: 389-394

  32. Nakai D, Yuasa S, Takahashi M, Shimizu T, Asaumi S, Isono K, Takao T, Suzuki Y, Kuroyanagi, H, Hirokawa K, Koseki H and Shirasawa T. Mouse homologue of Coq7/Clk-1, longevity gene in C. elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis. Biochem Biophys Res Commun. 2001; 289: 463-471.

  33. Levavasseur F, Miyadera H, Sirois J, Tremblay ML, Kita K, Shoubridge E, Hekimi S. Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration. J Biol Chem. 2001; 276: 46160-46164.

  34. Takahashi M, Asaumi S, Honda S, Suzuki Y, Nakai D, Kuroyanagi H, Shimizu T, Honda Y, Shirasawa T. (2001) Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans. Biochem Biophys Res Commun. 286: 534-540

  35. B. Lakowski & S. Hekimi (1998) The genetics of caloric restriction in Caenorhabditis elegans Proc Natl Acad Sci USA 95, 13091-13096

  36. J. Apfeld & C. Kenyon (1999) Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-809

  37. M. Ailion T. Inoue, I. C.I. Weaver, R. W. Holdcraft, & J. H. Thomas (1999) Neurosecretory control of aging in Caenorhabditis elegans. Proc Natl Acad Sci USA 96, 7393-7397

  38. S. Paradis et al (1999) A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Gene Dev 13, 1438-1452

  39. M. I. Snow & P. L. Larsen (2000) Structure and expression of daf-12: a nuclear hormone receptor with three isoforms that are involved in development and aging in Caenorhabditis elegans. BBA 1494, 104-116

  40. B. Lakowski & S. Hekimi (1998) Proc Natl Acad Sci USA 95, 13091-13096

  41. J. Apfeld & C. Kenyon (1999) Nature 402, 804-809

  42. M. Ailion et al (1999) Proc Natl Acad Sci USA 96, 7393-7397

  43. S. Paradis et al (1999) Gene Dev 13, 1438-1452

  44. M. I. Snow & P. L. Larsen (2000) BBA 1494, 104-116